Oxford Nanopore Technologies Ltd

The following publications have been generated by Oxford Nanopore Technologies or our academic collaborators.

Publications related to sequencing DNA and RNA

Strand sequencing

Single Molecule RNA Base Identification with a Biological Nanopore. Biophysical Journal 102 (2012): 429.

Slowing down DNA translocation through a nanopore in lithium chloride. Nano Letters 12:1038-1044 (2012).

DNA base-calling from a nanopore using a Viterbi algorithm. Biophysical Journal Letters 102:L37-L39 (2012).

Thermophoretic Manipulation of DNA Translocation through Nanopores.  ACS nano (2012).

Processive replication of single DNA molecules in a nanopore catalyzed by ph29 DNA polymerase. Journal of the American Chemical Society 132 (50), 17961-17972 (2010)

Identification of epigenetic DNA modifications with a protein nanopore. Chemical Communications 46 (43), 8195-8197 (2010)

Replication of individual DNA molecules under electronic control using a protein nanopore. Nature Nanotechnology 5 (11), 798-806 (2010)

Nucleobase recognition in ssDNA at the central constriction of the alpha hemolysin pore. Nano Letters 10 (9), 3633-3637 (2010)

 

Multiple base recognition sites in a biological nanopore: two heads are better than one. Angewandte Chemie International Edition 49 (3), 556-559 (2010)

Single-nucleotide discrimination in immobilized DNA oligonucleotides with a biological nanopore. Proceedings of the National Academy of Sciences of the USA 106 (19), 7702-7707 (2009)

Sequence-specific detection of individual DNA strands using engineered nanopores. Nature Biotechnology 19 (7), 636-639 (2001)

Exonuclease sequencing

Continuous base identification for single-molecule nanopore DNA sequencing. Nature Nanotechnology 4 (4), 265-270 (2009)

Toward single molecule DNA sequencing. Journal of the Americal Chemical Society 128 (5), 1705-1710 (2006)

Publications related to Protein Analysis

Multistep protein unfolding during nanopore translocation. Nature Nanotechnology (2013). 

Unfoldase-mediated protein translocation through an α-hemolysin Nanopore.  Nature biotechnology (2013).

Protein detection by nanopores equipped with aptamers.  Journal of the American Chemical Society 134.5 (2012): 2781-2787.

Controlling protein translocation through nanopores with bio-inspired fluid walls.  Nature Nanotechnology 6, 253–260 (2011).

Publications related to Nanopores as Biosensors

DNA origami nanopores.  Nano letters 12.1 (2011): 512-517.

Single molecule detection of nitrogen mustards by covalent reaction within a protein nanopore. Journal of the American Chemical Society 130 (21), 6813-6819 (2008)

Protein Nanopores with covalently attached molecular adapters. Journal of the American Chemical Society 129 (151), 16142-16148 (2007)

Direct transfer of membrane proteins from bacteria to planar bilayers for rapid screening by single-channel recording. Nature Chemical Biology 2 (6), 314-318 (2006)

Stochastic sensing of enantiomers. Journal of the American Chemical Society 128 (33), 10684-10685 (2006)

A genetically encoded pore for the stochastic detection of a protein kinase. ChemBioChem 7 (12), 1923-1927 (2006)

Direct introduction of single protein channels and pores into lipid bilayers. Journal of the American Chemical Society 127 (18), 6502-6503 (2005)

Stochastic detection of monovalent and bivalent protein-ligand interactions. Angewandte Chemie International Edition 43 (7), 842-846 (2004)

Stochastic sensing of TNT with a genetically engineered pore. ChemBioChem 6 (10), 1875-1881 (2005)

Kinetics of a reversible covalent-bond forming reaction observed at the single-molecule level. Angewandte Chemie International Edition 41 (19), 3707-3709 (2002)

Capture of a single molecule in a nanocavity. Science 291 (5504), 636-640 (2001)

Publications related to Solid-State Nanopores

Assessing graphene nanopores for sequencing DNA. Nano Letters 12:4117-4123 (2012).

Translocating Single-Stranded DNA through Crystalline Graphene Nanopores Biophysical Journal 102 (2012): 728.

Slowing down and stretching DNA with an electrically tunable nanopore in a p–n semiconductor membrane.  Nanotechnology 23.25 (2012): 255501

A Stacked Graphene-Al2O3 Nanopore Architecture for DNA Detection.  Biophysical Journal 102 (2012): 730.

Local electrical potential detection of DNA by nanowire-nanopore sensors. Nature Nanotechnology 7 (2), 119-125 (2012)

Hybrid pore formation by directed insertion of alpha hemolysin into solid-state nanopores. Nature Nanotechnology 5 (12), 874-877 (2010)

Graphene as a sub nanometre trans-electrode membrane. Nature 467 (7312), 190-193 (2010)
Accompanying editorial by Professor Hagan Bayley

Ice Lithography for Nanodevices. Nano Letters 10 (12), 5056-5059 (2010)

Recapturing and trapping single molecules with a solid-state nanopore. Nature Nanotechnology 2 (12), 775-779 (2007)

DNA conformation and base number simultaneously determined in a nanopore. Electrophoresis 28 (18), 3186-3192 (2007)

Review articles

DNA sequencing with nanopores. Nature Biotechnology 30, 326–328 (2012)

Solid-state Nanopores Nature Nanotechnology 2 (4), 209-215 (2007)

Nanopore analysis of nucleic acids bound to exonucleases and polymerases. Annual Review of Biophysics 39, 79-90 (2010)

The potential and challenges of nanopore sequencing. Nature Biotechnology 26 (10), 1146-1153 (2008)
 

Sequencing single molecules of DNA. Current Opinion in Chemical Biology 10 (6), 628-637 (2006)

Stochastic sensors inspired by biology. Nature 413 (6852), 226-230 (2001)

Stochastic sensing with protein pores. Advanced Materials 12 (2), 139-142 (2000)

Building doors into cells. Scientific American 277 (3), 62-67 (1997)