Oxford Nanopore Technologies Ltd

MinION is a pocket-sized portable device used for real-time biological analysis. It is adaptable to the analysis of DNA, RNA, or proteins. MinION's simple workflow allows end-to-end experiments in many environments.

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PromethION combines MinION's simplicity of use with greater workflow flexibility through scale and a modular design. Increase throughput by analysing the same sample simultaneously in multiple flow cells, or run different samples concurrently.

The GridION system, currently in development, is a scalable real-time analysis system designed to analyse single molecules such as DNA, RNA and proteins.

Metrichor provides a cloud-based platform for real time analysis of data from nanopore devices. Applications available through Metrichor will expand with the ultimate goal of enabling the analysis of any living thing, by any user, in any environment.

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Technology advisory board - Professor David Deamer
Professor David Deamer
Professor David Deamer
University of California, Santa Cruz (UCSC)
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Professor David Deamer was founder of the UCSC Nanopore Project, which is now co-directed by Professor Mark Akeson and involves faculty collaborators from UCSC and other institutions. The project received a “$1000 Genome” grant from the NHGRI in 2005.

In 1996, Professor Deamer was a co-author on the paper that first demonstrated single-molecule analysis of nucleic acids using the alpha hemolysin nanopore. Professor Deamer and his collaborators now investigate physical properties of ‘single-stranded’ DNA and RNA molecules, with the aim of using alpha hemolysin to determine base sequences of nucleic acids. The team uses two approaches to analyze DNA in this way. In the first, a constant applied voltage pulls single-stranded DNA or RNA through the pore, permitting discrimination among single polymer molecules based on their nucleotide composition. The second approach is to capture a single duplex DNA molecule in the channel vestibule. Duplex DNA is too large to pass through the nanopore, but the molecular motions of the base pairs occupying the vestibule can be monitored in real time for tens-to-hundreds of milliseconds. In this voltage-pulse or 'tasting' mode, single base-pair resolution is achieved, suggesting that nanopore detection of single nucleotide polymorphisms (SNPs) is feasible.