Oxford Nanopore Technologies Ltd

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Oxford Nanopore congratulates Professor Reza Ghadiri and collaborators on $5.1 million NHGRI grant

-award will support research into sequencing of single stranded DNA using a protein nanopore-

14 September 2010, Oxford, UK. Oxford Nanopore Technologies Ltd is pleased to congratulate Professor Reza Ghadiri (Scripps Institute, CA, USA) on the award of a $5.1 million, four year grant by the National Human Genome Research Institute (NHGRI). Professor Ghadiri will collaborate with Oxford Nanopore founder Professor Hagan Bayley (University of Oxford, UK) and Professor Amit Meller (Boston University) on the grant, entitled “Single-Molecule DNA Sequencing with Engineered Nanopores”. 

The research laboratories in the US and UK will collaborate to research the use of biological nanopores for sequencing single stranded DNA (ssDNA), for the development of a new method of faster and cheaper DNA analysis technology. Specific projects will address enzymatic and non-enzymatic mechanisms of controlling the translocation of ssDNA through the nanopore and the accurate identification of individual DNA bases on the strand as it passes through the pore.

Nanopore sensing can be scaled-up through the use of massively parallel array chips, where individual electronic channels correspond with individual nanopores. The NHGRI-funded programme will also include research on new types of arrays, including the insertion of protein nanopores into silicon nitride films and measurement of ion flow through these pores using fluorescence detection.

The award is part of the “$1,000 genome” technology programme, designed to reduce dramatically the cost of DNA sequencing and broaden the applications of genomic information in medical research and health care.

The project will build on work conducted with a previous award; $4.2 million was awarded to the same researchers for “Single-Molecule DNA Sequencing with Engineered Nanopores” in 2005.

For more information please use the following links:

  • NHGRI: http://www.genome.gov/27541190
  • Ghadiri lab http://www.scripps.edu/chem/ghadiri/
  • Bayley lab http://bayley.chem.ox.ac.uk/
  • Oxford Nanopore Technologies: http://www.nanoporetech.com

Notes to Editors

About Oxford Nanopore Technologies

Oxford Nanopore is developing a revolutionary platform technology for direct, electrical detection and analysis of single molecules, with a lead application of DNA sequencing. The Company was founded in 2005 on the science of Professor Hagan Bayley of the University of Oxford and has since formed a series of collaborations with other leading institutions including Harvard University and the University of California, Santa Cruz.

Oxford Nanopore’s modular instrumentation may be combined with different types of nanopore sensor for the analysis of a range of single molecules. The Company’s ‘exonuclease sequencing’ method combines a processive enzyme with a protein nanopore for the identification of individual bases cleaved sequentially from a DNA strand. ‘Strand sequencing’ is a method to identify bases on an intact strand of DNA as it passes through a protein nanopore. Future generations of nanopore sensing technology may use ‘solid-state’ nanopores, holes in synthetic materials. 

The platform is also adaptable for protein analysis for diagnostics and drug development and identification of a range of other molecules for security & defence and environmental monitoring. The technology is highly scalable, driven by electronics rather than optics. For more information visit www.nanoporetech.com, including a list of relevant publications at http://www.nanoporetech.com/sections/index/17.

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Oxford Nanopore congratulates Professor Reza Ghadiri and collaborators on $5.1 million NHGRI grant